Asah1 inhibitor
Web24 apr 2013 · Recently, targeting ASAH1 for cancer treatments has generated significant interest, as reported by multiple studies, which identified ASAH1 as a therapeutic target. … Web27 mag 2024 · Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human melanoma cell lines...
Asah1 inhibitor
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Further, ASAH1 inhibition resensitized resistant MM cells to PI treatment. Importantly, we recapitulated our findings in CD138+ patient MM cells ex vivo (EMMA platform), with ceranib-2/PI treatment being synergistic in the majority (>75%) of patient samples tested. Web27 mag 2024 · In this study, we compared transcriptomes of parental cancer cells and PGCC in the absence or presence of the ASAH1 inhibitor LCL521. Results show that PGCC express less INSIG1, ...
Web19 dic 2024 · Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this issue in K562 cells, a cellular model of the human chronic myeloid leukemia. Here, we applied stable … Web8 dic 2024 · Clinical resource with information about ASAH1, A genome-wide association study on obesity and obesity-related traits., Farber lipogranulomatosis, Spinal muscular …
WebNational Center for Biotechnology Information Web1 dic 2024 · ASAH1 inhibitor Carmofur neutralized the protective effect of HLD on LPS-induced ALI To confirm whether the protective effect of HLD on ALI was neutralized when the sphingolipid signaling pathway was inhibited, H&E staining was used to determine histological changes in lung tissues ( Fig. 8 A).
Web1 feb 2012 · We show that ASAH1 suppression increases the transcription of multiple steroidogenic genes, including Cytochrome P450 monooxygenase (CYP)17A1, CYP11B1/2, CYP21A2, steroidogenic acute regulatory protein, hormone-sensitive lipase, 18-kDa translocator protein, and the melanocortin-2 receptor.
WebSimilarly, a dual SPHK1/2 inhibitor developed by Amgen, “Compound A”, did not inhibit cancer cell proliferation or survival and had no effect as a single agent in a mouse breast cancer xenograft model, ... ASAH1 expression has been positively correlated with Akt phosphorylation in prostate cancer tissues [176,177]. published是什么意思中文Web人生长调节致癌基因γ（groγ）elisa检测试剂盒 返回列表页 publisheet add-in paneWeb23 nov 2024 · Preliminary studies from our group have identified that the therapeutically targetable acid ceramidase, ASAH1, is a key mediator of PI resistance and its presence … publisheetWebAs shown in Figure 1E, the expression of ceramide synthases (Cers4 and Cers5), acid ceramidase (Asah1), N-acylethanolamine acid amidase (Naaa), and beta-1,3-galactosyltransferase (4B3galt4) and β-galactoside α-2,3-sialyltransferase 2 (St3gal2), two key enzymes involved in the synthesis of GM1 ganglioside [24,25], was significantly … published works of francisco arcellanaWeb5 mar 2024 · ASAH1 is required during the 2-4 cell blastomere stage during embryonic development but is largely dispensable in somatic cells as demonstrated by nearly … published是什么意思Web3 feb 2024 · As depicted in Fig. 4A, P i treatment in CASMCs isolated from Asah1 fl/fl /SM Cre mice increased calcium deposition compared to WT/WT cells whileas GW4869, sEV release inhibitor, significantly ... published翻译WebASAH1 Inhibitors The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Simply search by “Keywords” if you know the name of the inhibitor, or search by “Inhibitor Target” to enter the name of your protein of interest. publish electron app